Targeted Disruption of the Murine Tissue Factor Gene
نویسندگان
چکیده
منابع مشابه
Targeted disruption of the murine tissue factor gene results in embryonic lethality.
Tissue factor (TF) is an integral membrane glycoprotein that is believed to be the physiologic initiator of the blood coagulation cascade. Disruption of the mouse tissue factor gene leads to embryonic lethality between days E9.5-E11.5 of gestation. On E9.5, TF(-/-) embryos appear indistinguishable from their TF(+/+) and TF(+/-) littermates. By E10.5, TF(-/-) embryos are severely growth retarded...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1997
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.8.153